Biogen Co-op: Computational Chemistry in Cambridge, Massachusetts
/This position is for a 6-month Co-op lasting from January - June 2022/ Computational chemistry group is seeking a co-op who will perform molecular dynamic simulations on RNA-small molecule complexes Position Description Targeting RNAs with small molecules offers opportunities to therapeutically modulate numerous cellular processes, including those linked to 'undruggable' protein targets. A good understanding of RNA - small molecule interactions is key to targeting RNAs. Riboswitches are relatively well characterized structurally, and several structures of small molecule bound riboswitches are available. In this role you will perform the following, including but not limited to: * Perform Molecular Dynamics simulations to characterize small molecule interactions with RNA and delineate them in comparison to small molecule protein interactions. * Compare forcefields across different software to find the best alternative for RNA simulations * Write reports and give presentations to internal/external audience * Publish the project work in peer reviewed scientific journals. * Experience in running molecular dynamic simulations and data analysis applying statistical methods * Working proficiency of computational chemistry software suite such as: Amber, Schrodinger, VMD * Expertise in Python, Shell programming and Linux/Unix system * Knowledge of RNA structures, receptor (protein/RNA)-ligand interactions is a plus To participate in the Biogen Co-op Program, students must meet the following eligibility criteria: * Legal authorization to work in the U.S. * At least 18 years of age prior to the scheduled start date * Be currently enrolled in an accredited college or university Education A Ph.D. student in computational chemistry or relevant field is preferred. All your information will be kept confidential according to EEO guidelines.