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Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .

The Oncology Thematic Research Center at BMS is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art research and development site in Cambridge focus on novel tumor intrinsic targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies and implement our discovery platforms across all of our therapeutic areas of focus. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of cancer biology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area.

The new Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities.

Position Responsibilities

In the role as a Sr. Principal Scientist within Discovery Pharmacology and In vivo Biology, the ideal candidate will:

• Function as Pharmacology lead for multiple T cell engager drug discovery programs. Working closely with project teams and key stakeholders, lead the development of in vivo strategies from target concept to Proof of Concept in patients, applying scientific and technical skills and functional knowledge to projects.

• Characterize therapeutic candidates in vivo as part of the lead selection process, including tumor target antigen expression, T cell immunophenotyping, T cell dependent cytotoxicity and cytokine release assays advancing novel research molecules towards development candidates and IND. Utilize strong foundational knowledge of building PK PD and efficacy relationship in vivo.

• Identify and develop state of the art in vivo models, experimental protocols and relevant IO assays. Strengthen department's overall T-cell engager capabilities and expertise by employing innovative methods and technologies to test therapeutic hypotheses.

• Working with cross-functional teams participate in development and implementation of program strategy, including integrating in vivo pharmacology strategy with toxicology and translational strategies to support regulatory filings

• Design, execute and deliver experiments comprehensive high quality data sets to drive decision making. Interpret results of complex experiments. Use relevant information, technology and resources, contributing to complex team problem resolution and goals. Proactively foster relationships across disciplines to facilitate decision making process.

• Communicate program strategy and timelines to management. Prepare and present comprehensive technical or project reports at governance meetings

• Manage a team of in vivo scientists providing guidance and mentoring to junior level scientists and Research associates. Outline clear development opportunities for direct reports. Will contribute to strategic discussions and goal setting with team

• Leads initiatives related to development of new approaches / technologies within T-Cell engager strategy. Encourages use of experimental / innovative approaches within group.

Experience =

Basic Qualifications:

• Bachelor's Degree

• 10+ years of academic and / or industry experience

Or

• Master's Degree

• 8+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

• 6+ years of academic and / or industry experience

• 2+ years of leadership experience

Preferred Qualifications:

• PhD immunology, cancer biology or relevant biological science with 6-8 years of relevant industry experience in in vivo pharmacology and a deep expertise in T cell biology and immune-oncology.

• Industry experience with a proven track record of independently driving in vivo strategy for immune cell engagers, including CD3 T cell engagers .

• Demonstrated ability to independently develop focused in vivo strategies and utilizing PK/PD/efficacy data to drive discovery, optimization, and characterization of CD3 T-cell engagers is required.

• Demonstrated leadership in developing and deploying novel in vivo models to enable immune cell engager, including T-cell engagers, drug discovery and translational research is required.

• Experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models to build in vivo strategies to enable candidate selection for early clinical development is highly desired.

• Demonstrated expertise in utilizing relevant pharmacodynamic assays such as MSD ELISAs, immune profiling by flow cytometry, Luminex

• Track record of building high functioning teams, managing and mentoring scientists in laboratory-based roles to support preclinical discovery research programs. Experience providing growth opportunities to team members to support their continued development.

• Excellent interpersonal and communication skills with the ability to interact effectively with internal and external colleagues are required.

• Competitive candidates are expected to have a strong track record of independent and innovative research.

#LI-Hybrid

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Company: Bristol-Myers Squibb

Req Number: R1590034

Updated: 2025-03-21 05:46:43.925 UTC

Location: Cambridge Crossing-MA

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.